Human hTM. cap alpha. gene: Expression in muscle and nonmuscle tissue

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Mol. Cell. Biol.; (United States)

DOI:https://doi.org/10.1128/MCB.8.1.433· OSTI ID:7077558

MacLeod, A R; Gooding, C

The authors isolated a cDNA clone from a human skeletal muscle library which contains the complete protein-coding sequence of a skeletal muscle ..cap alpha..-tropomyosin. This cDNA sequence defines a fourth human tropomyosin gene, the hTM..cap alpha.. gene, which is distinct from the hTM/sub nm/ gene encoding a closely related isoform of skeletal muscle ..cap alpha..-tropomyosin. In cultured human fibroblasts, the hTM..cap alpha.. gene encodes both skeletal-muscle- and smooth-muscle-type ..cap alpha..-tropomyosins by using an alternative mRNA-splicing mechanism.

• Research Organization: Ludwig Institute for Cancer Research, MRC Centre, Hills Road, Cambridge CB2 2QH (GB)
• OSTI ID: 7077558
• Journal Information: Mol. Cell. Biol.; (United States), Journal Name: Mol. Cell. Biol.; (United States) Vol. 8:1; ISSN MCEBD
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL PATHWAYS
CELL CULTURES
CLONING
CONNECTIVE TISSUE CELLS
DNA SEQUENCING
DNA-CLONING
FIBROBLASTS
GENE REGULATION
GENES
MAMMALS
MAN
MUSCLES
PHENOTYPE
PRIMATES
RNA PROCESSING
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
TROPOMYOSIN
VERTEBRATES