Molecular cloning and chromosomal localization of the human [alpha][sub 7]-nicotinic receptor subunit gene (CHRNA7)

Journal Article · Sat Jan 15 04:00:00 EST 1994 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1994.1075· OSTI ID:7077264

Chini, B; Raimond, E; Moralli, D; Balzaretti, M ^[1]; Elgoyhen, A B; Heinemann, S ^[2]

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1. Dip. Genetica e Microbioligia, Pavia (Italy)
2. Salk Institute, La Jolla, CA (United States)

The authors have isolated cDNA and genomic clones coding for the human [alpha][sub 7] neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by [alpha]-bungarotoxin. The human [alpha][sub 7] neuronal nicotinic cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat [alpha][sub 7] neuronal nicotinic subunit (90%). The authors have mapped the human [alpha][sub 7]-nicotinic receptor subunit gene to chromosome 15, band q14, a region frequently rearranged in patients carrying a bisatellite 15 chromosome, large inv dup (15), whose clinical features include mental retardation and seizures. 15 refs., 2 figs.

• OSTI ID: 7077264
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 19:2; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AUTONOMIC NERVOUS SYSTEM AGENTS
CHROMOSOMES
CLONING
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
DRUGS
GENES
GENETIC MAPPING
HUMAN CHROMOSOME 15
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
MEMBRANE PROTEINS
MENTAL DISORDERS
ORGANIC COMPOUNDS
PARASYMPATHOLYTICS
PROTEINS
RECEPTORS
STRUCTURAL CHEMICAL ANALYSIS