Cloning and mapping of the mouse {alpha}7-neuronal nicotinic acetylcholine receptor

Journal Article · Mon Mar 20 04:00:00 EST 1995 · Genomics

DOI:https://doi.org/10.1016/0888-7543(95)80228-E· OSTI ID:219905

Orr-Urtreger, A; Baldini, A; Beaudet, A L ^[1]

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1. Howard Hughes Medical Institute, Houston, TX (United States); and others

We report the isolation of cDNA clones for the mouse {alpha}7 neuronal nicotinic acetylcholine receptor subunit (gene symbol Acra7), the only nicotinic receptor subunit known to bind a-bungarotoxin in mammalian brain. This gene may have relevance to nicotine sensitivity and to some electrophysiologic findings in schizophrenia. The mouse {alpha}7 subunit gene encodes a protein of 502 amino acids with substantial identity to the rat (99.6%), human (92.8%), and chicken (87.5%) amino acid sequences. The {alpha}7 gene was mapped to mouse chromosome 7 near the p locus with the following gene order from proximal to distal: Myod1-3.5 {+-}1.7 cM-Gas2-0.9 cM {+-} 0.9 cM-D7Mit70-1.8 {+-} 1.2 cM- Acra7-4.4 {+-}1.0 cM-Hras1-ps11/Igf1r/Snrp2a. The human gene was confirmed to map to the homologous region of human chromosome 15q13-q14. 26 refs., 3 figs.

• OSTI ID: 219905
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 26; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
ACETYLCHOLINE
AMINO ACID SEQUENCE
DNA-CLONING
GENES
GENETIC MAPPING
HUMAN CHROMOSOME 15
MICE
NICOTINE
PROTEINS
RECEPTORS