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Stimulation of 25-hydroxyvitamin D/sub 3/-1. cap alpha. -hydroxylase by estrogen

Journal Article · · Arch. Biochem. Biophys.; (United States)
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Homogenates of kidney from laying Japanese quail incubated in vitro with 25-hydroxy-(26,27-/sup 3/H)vitamin D/sub 3/ produce more 1,25-dihydroxy-(26,27-/sup 3/H)vitamin D/sub 3/ than do homogenates of kidney from mature nonlaying females or males maintained on the same diet and under identical conditions. Instead, the homogenates from male quail or nonlaying female quail convert 25-hydroxyvitamin D/sub 3/ to 24,25-dihydroxyvitamin D/sub 3/. The administration of 5 mg of estradiol to mature male quail 24 h prior to sacrifice suppressed the 25-hydroxyvitamin D/sub 3/-24-hydroxylase and markedly stimulated 25-hydroxyvitamin D/sub 3/-1-hydroxylase. The administration of estradiol to male quail caused hypercalcemia, which responded more slowly than did the 1-hydroxylase. As little as 0.1 mg of estradiol/quail was found effective in stimulating the 1-hydroxylase and suppressing the 24-hydroxylase. Other hormones such as follicle stimulating hormone (FSH), cortisone, testosterone, and progesterone, even at high dose levels, produced little or no change in the 25-hydroxyvitamin D/sub 3/-1-hydroxylase. Testosterone did, however, suppress the 25-hydroxyvitamin D/sub 3/-24-hydroxylase. The stimulation of the 25-hydroxyvitamin D/sub 3/-1-hydroxylase by parathyroid hormone was of a smaller magnitude than that of the estradiol, and the effects of the two hormones were additive, suggesting that they function by a different mechanism.

Research Organization:
Univ. of Wisconsin, Madison
OSTI ID:
7076061
Journal Information:
Arch. Biochem. Biophys.; (United States), Journal Name: Arch. Biochem. Biophys.; (United States) Vol. 179; ISSN ABBIA
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALKALINE EARTH METALS
ANDROGENS
ANDROSTANES
ANIMALS
BIOCHEMISTRY
BIRDS
BODY
CALCIUM
CHEMISTRY
CHOLECALCIFEROL
CORTICOSTEROIDS
CORTISONE
ELEMENTS
ENDOCRINE GLANDS
ENZYMES
ESTROGENS
FSH
GLANDS
GLUCOCORTICOIDS
GONADOTROPINS
HORMONES
HYDROXY COMPOUNDS
HYDROXYLASE
INHIBITION
KETONES
KIDNEYS
METABOLISM
METALS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PARATHORMONE
PARATHYROID GLANDS
PEPTIDE HORMONES
PITUITARY HORMONES
PREGNANES
PROGESTERONE
PROTEINS
SEX DEPENDENCE
STEROID HORMONES
STEROIDS
STIMULATION
TESTOSTERONE
VERTEBRATES
VITAMIN D
VITAMINS