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Control of renal vitamin D hydroxylases in birds by sex hormones

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
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Kidney homogenates from adult male Japanese quail or chickens demonstrate hydroxylase activity predominantly fo the 24 rather than the 1 position of 25-hydroxyvitamin D/sub 3/ (25-hydroxycholecalciferol). A single injection of 5 mg of estradiol-17..beta.. into a male bird completely suppresses the 24-hydroxylase and greatly increase the 1-hydroxylase activity. Immature males do not respond well to estrogen alone, but they do respond well to estradiol plus testosterone. Testosterone alone has little or no effect on the hydroxylases of either species. Castrated male chickens show an estradiol response only when testosterone is also given. Optimal 24 hr responses to 5 mg of estradiol per kg in the castrate male were obtained with about 12 mg of testosterone per kg. These optimal amounts of estradiol and testosterone increased the activity of 25-hydroxyvitamin D/sub 3/-1-hydroxylase approximately 225-fold (this enzyme is also known as 25-hydroxycholecalciferol 1-monooxygenase; 25-hydroxycholecalciferol, NADPH: oxygen oxidoreductase (hydroxylating), EC 1.14.13.13). These results demonstrate a strong regulation by the sex hormones of the renal vitamin D hydroxylases in birds.
Research Organization:
Univ. of Wisconsin, Madison
OSTI ID:
5734531
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 73:8; ISSN PNASA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANDROGENS
ANDROSTANES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIRDS
BODY
CARBON 14
CARBON ISOTOPES
CHOLECALCIFEROL
ESTRADIOL
ESTRANES
ESTROGENS
EVEN-EVEN NUCLEI
HORMONES
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
HYDROXYLATION
ISOTOPES
KETONES
KIDNEYS
LIGHT NUCLEI
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
STEROID HORMONES
STEROIDS
TESTOSTERONE
TRITIUM
VERTEBRATES
VITAMIN D
VITAMINS
YEARS LIVING RADIOISOTOPES