Inhalation imaging with oxygen-15 labeled carbon dioxide for detection and quantitation of left-to-right shunts

Journal Article · Sat Oct 01 04:00:00 EDT 1977 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.56.4.632· OSTI ID:7075968

Boucher, C A; Ahluwalia, B; Block, P C; Brownell, G L; Beller, G A

Quantitation of left-to-right shunts was determined noninvasively from the pulmonary clearance pattern of inhaled /sup 15/oxygen-labeled carbon dioxide (C/sup 15/O/sub 2/). After a single breath inhalation of C/sup 15/O/sub 2/, counts over the lungs were obtained from sequential 0.5 sec positron camera images. In 21 patients without left-to-right shunts, counts declined exponentially due to the washout of C/sup 15/O/sub 2/ by the pulmonary blood flow. In 22 patients with left-to-right shunts, this monoexponential pulmonary clearance pattern was interrupted by an abnormal upward deviation, indicating tracer recirculation through the shunt to the lungs. Following surgical shunt closure in 10 patients, pulmonary C/sup 15/O/sub 2/ clearance patterns became normal in nine and showed a small residual left-to-right shunt in one. Shunt size was derived from the ratio of the height of the recirculation curve to the height of the initial inhalation peak. These values significantly correlated with shunt size as determined by oximetry (r = 0.83).

• Research Organization: Harvard Medical School, Boston
• OSTI ID: 7075968
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 56:4; ISSN CIRCA
• Country of Publication: United States
• Language: English

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD CIRCULATION
BODY
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARDIOVASCULAR SYSTEM
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COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
EVEN-ODD NUCLEI
HEART
INHALATION
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
LUNGS
MEASURING METHODS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ORGANS
OXIDES
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
SURGERY
TRACER TECHNIQUES