Quantitative radionuclide angiocardiography for left-to-right cardiac shunts in children

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Pediatr. Cardiol.; (United States)

DOI:https://doi.org/10.1007/BF02082322· OSTI ID:5996173

Smallhorn, J F; Adams, A P; Goldblatt, E; Savage, J P

Pulmonary to systemic flow ratios (Qp/Qs) were estimated by quantitative radionuclide angiocardiography (QRAC) in 135 children. The Qp/Qs ratios were derived from pulmonary time/activity curves using a gamma variate model. Eighty-five of these children also had Qp/Qs ratios estimated by oximetry at cardiac catheterization. Left-to-right shunts with a Qp/Qs range of 1.2 to 3.0 were detected and quantitated by radionuclide angiography with an accuracy similar to that for oximetry. The correlation between Qp/Qs, determined by QRAC and by oximetry was good (r . .93; SEE .31). This relatively noninvasive technique has now been used to estimate the Qp/Qs ratio in 34 children with a clinically suspected left-to-right shunt, and postoperatively in 16 cases with residual murmurs; it has obviated the need for catheterization in many of these patients. The technique may also be used serially to determine changes in the Qp/Qs ratio in patients with known left-to-right shunts.

• Research Organization: Department of Cardiology, Adelaide Children's Hospital, North Adelaide, South Australia
• OSTI ID: 5996173
• Journal Information: Pediatr. Cardiol.; (United States), Journal Name: Pediatr. Cardiol.; (United States) Vol. 3:1; ISSN PECAD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
BLOOD CIRCULATION
BODY
CARDIOGRAPHY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHILDREN
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DRUGS
HEART
LABELLED COMPOUNDS
ORGANS
PATHOLOGY
PATIENTS
RADIOCARDIOGRAPHY
RADIOISOTOPE SCANNING
RADIOPHARMACEUTICALS
SCINTISCANNING
USES