A microsatellite-based multipoint index map of human chromosome 22

Journal Article · Sun Oct 31 23:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1473· OSTI ID:7075761

Buetow, K H; Duggan, D; Yang, B; Ludwigsen, S ^[1]; Puck, J; Porter, J; Budarf, M; Emanuel, B S ^[2]; Spielman, R ^[3]

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1. Fox Chase Cancer Center, Philadelphia, PA (United States)
2. Children's Hospital of Philadelphia, PA (United States)
3. Univ. of Pennsylvania, Philadelphia, PA (United States)

Utilizing the CEPH (Centre d'Etude du Polymorphisme Humain) references panel and genotyping data for 24 simple tandem repeat polymorphism (STRP) markers, the authors have constructed a 15-locus multipoint genetic framework map of human chromosome 22. The markers form a continuous linkage group of 51 cM in males and 81 cM in females. Likely genetic locations are provided for 9 additional STRP sequences. The map was constructed employing the CRIMAP computational methodology to build the multipoint map via a stepwise algorithm. The quality of the framework map was evaluated using a battery of statistical diagnostics that suggest a typing error frequency of 0.1% for markers within the map. 27 refs., 3 figs., 3 tabs.

• OSTI ID: 7075761
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 18:2; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS
990200 -- Mathematics & Computers
CHROMOSOMES
GENETIC MAPPING
HUMAN CHROMOSOME 22
HUMAN CHROMOSOMES
MAPPING
PROGRAMMING
RFLPS