In vitro cellular radiosensitivity of human malignant melanoma

Journal Article · Thu Jul 01 00:00:00 EDT 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90074-8· OSTI ID:7067248

Selby, P J; Courtenay, V D

The agar diffusion chamber assay was used to construct in vitro radiation cell survival curves for two human malignant melanoma xenografts. Both tumors had survival curves of shoulder-exponential shape with large shoulders (Dq 2.38, 2.92 Gy). Comparison with previous studies of 4 human tumor xenografts in the same system suggests that large shoulders are more common in melanomas than other tumor types. This supports the case for large fraction irradiation in the clinical therapy of melanoma.

• Research Organization: Princess Margaret Hospital, Toronto, Ontario, Canada
• OSTI ID: 7067248
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:7; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGY
DISEASES
FRACTIONATED IRRADIATION
GRAFTS
IN VITRO
IRRADIATION
MAMMALS
MAN
MEDICINE
MELANOMAS
NEOPLASMS
NUCLEAR MEDICINE
PRIMATES
RADIOBIOLOGY
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SURVIVAL CURVES
THERAPY
TRANSPLANTS
TUMOR CELLS
VERTEBRATES