Response of human malignant melanoma xenografts to hyperthermia: effect of vascular occlusion
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Two human malignant melanomas from two patients, grown subcutaneously in the leg of athymic nude mice, were exposed to hyperthermia (42.5/sup o/C) for varying times. Single cell survival was assayed in vitro in soft agar. The sensitivity to heat of the tumor cells was considerably enhanced when the blood supply to the tumors was occluded 15 min before and during treatment. The D/sub 0/-values of the survival curves were 86 min (unclamped) and 13 min (clamped) for E.E. melanoma and 25 min (unclamped) and 11 min (clamped) for V.N. melanoma.
- Research Organization:
- Norwegian Radium Hospital, Oslo
- OSTI ID:
- 5628784
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:12; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BODY TEMPERATURE
DISEASES
HYPERTHERMIA
MAMMALS
MEDICINE
MELANOMAS
MICE
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL CURVES
THERAPY
TUMOR CELLS
VERTEBRATES
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BODY TEMPERATURE
DISEASES
HYPERTHERMIA
MAMMALS
MEDICINE
MELANOMAS
MICE
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL CURVES
THERAPY
TUMOR CELLS
VERTEBRATES