Hyperthermic radiosensitization of cells from a human melanoma xenograft
Journal Article
·
· Radiat. Res.; (United States)
Cells derived directly from a human melanoma xenograft were exposed to radiation and/or hyperthermia under aerobic conditions in vitro. Single cell survival was assayed in soft agar. The activation energies for heat treatment alone were 420 +/- 40 kcal/mole (41.5-42.5/sup 0/C) and 170 +/- 10 kcal/mole (43.0-45.5/sup 0/C). Heat doses of 41.5/sup 0/C (30 min) or 43.5/sup 0/C (30 min) did not cause a reduction in the shoulder of the X-ray survival curve of the cells, but the D/sub 0/ value was reduced. The thermal enhancement ratios (the ratio of the D/sub 0/ values) were in the ranges 1.0-1.3 (41.5/sup 0/C, 30 min) and 1.1-1.7 (43.5/sup 0/C, 30 min), depending on the sequence and the time between the treatments. Repair of sublethal radiation damage was not significantly inhibited when treatments with 41.5/sup 0/C (30 min) or 43.5/sup 0/C (30 min) preceded irradiation, but was inhibited when 44.5/sup 0/C (30 min) was given immediately before radiation and when 4l.5/sup 0/C (120 min) was given immediately after radiation. Implications of the results for clinical treatment of malignant melanomas are discussed.
- Research Organization:
- Norwegian Radium Hospital, Oslo
- OSTI ID:
- 6600856
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560201 -- Thermal Effects-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTIVATION ENERGY
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CELL KILLING
DATA
DISEASES
ELECTROMAGNETIC RADIATION
ENERGY
EXPERIMENTAL DATA
HYPERTHERMIA
IN VITRO
INFORMATION
IONIZING RADIATIONS
MAMMALS
MAN
MELANOMAS
NEOPLASMS
NUMERICAL DATA
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SURVIVAL CURVES
TUMOR CELLS
VERTEBRATES
X RADIATION
560201 -- Thermal Effects-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTIVATION ENERGY
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
CELL KILLING
DATA
DISEASES
ELECTROMAGNETIC RADIATION
ENERGY
EXPERIMENTAL DATA
HYPERTHERMIA
IN VITRO
INFORMATION
IONIZING RADIATIONS
MAMMALS
MAN
MELANOMAS
NEOPLASMS
NUMERICAL DATA
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SURVIVAL CURVES
TUMOR CELLS
VERTEBRATES
X RADIATION