Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Radiosensitivity and recovery from radiation damage in cultured CHO cells exposed to hyperthermia at 42. 5 or 45. 5/sup 0/C

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575104· OSTI ID:5638383
; ;
The effect of hyperthermic treatments (42.5 or 45.5/sup 0/C) on recovery from radiation damage has been examined. Recovery from sublethal damage (SLD) when heat was administered prior to irradiation was not inhibited by small heat treatments survival reduced to 80% by 30 min at 42.5/sup 0/C or 4 min at 45.5/sup 0/C) for either temperature, but recovery was inhibited by larger heat treatments (survival reduced to 10% by 120 min at 42.5/sup 0/C or 15 min at 45.5/sup 0/C). Thus, the effects of 42.5 or 45.5/sup 0/C on recovery from SLD were similar when the heat treatments resulting in equal survival levels were used. Recovery from potentially lethal damage (PLD), as measured by incubation at 20/sup 0/C after a combination of radiation and heat treatments was observed when a small heat treatement (30 min at 42.5/sup 0/C) was given either before or after irradiation. The amount of radiosensitization, i.e., the thermal enhancement ratio (TER), calculated at the survival level of 10/sup -3/, correlated with the amount of cell killing resulting from the heat exposure alone, irrespective of the temperature at which the cells were treated.
Research Organization:
Colorado State Univ., Fort Collins
OSTI ID:
5638383
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 79:2; ISSN RAREA
Country of Publication:
United States
Language:
English

Similar Records

Combined effects of x irradiation and hyperthermia on CHO cells for various temperatures and orders of application
Journal Article · Tue Jan 31 23:00:00 EST 1978 · Radiat. Res.; (United States) · OSTI ID:7075822
Response of mouse adenocarcinoma cells to hyperthermia and irradiation
Journal Article · Sat Mar 31 23:00:00 EST 1979 · Radiat. Res.; (United States) · OSTI ID:6355116
Effect of hyperthermia on CHO DNA polymerases. cap alpha. and. beta
Journal Article · Thu Dec 31 23:00:00 EST 1981 · Radiat. Res.; (United States) · OSTI ID:5572192

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BODY TEMPERATURE
CELL CULTURES
CELL KILLING
ELECTROMAGNETIC RADIATION
FEMALE GENITALS
GONADS
HAMSTERS
HYPERTHERMIA
IONIZING RADIATIONS
MAMMALS
ORGANS
OVARIES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RECOVERY
RODENTS
SURVIVAL TIME
SYNERGISM
TEMPERATURE EFFECTS
TIME DEPENDENCE
VERTEBRATES
X RADIATION