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Radiosensitivity of nall human melanoma transplanted into nude mice: repair, reoxygenation and dose fractionation. [Gamma radiation]

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Split dose and fractionated ..gamma..-rays experiments have been performed on a human melanoma transplanted into nude mice using an in vitro colony assay. Repair of potentially lethal damage observed after a single dose of 20 Gy was found to no longer occur when 7 daily doses of 2.5 Gy were administered. In split-dose experiments, the increase in survival level probably can not be explained by repair of sublethal damage. When a single high dose of radiation is administered a certain reoxygenation is observed; however, there is no reoxygenation when low radiation doses are delivered daily.
OSTI ID:
7067221
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:6; ISSN IOBPD
Country of Publication:
United States
Language:
English