Occupational and environmental exposure to lead and Paget's disease of bone

Journal Article · Fri Dec 31 23:00:00 EST 1993 · Environment International; (United States)

DOI:https://doi.org/10.1016/0160-4120(94)90008-6· OSTI ID:7065884

Spencer, H; Sontag, S J ^[1]

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1. VA Hospital, Hines, IL (United States)

This paper reports an association between lead exposure and Paget's disease of bone. Detailed interviews of occupational or environmental exposure to lead established this association in 44 of 48 male patients, i.e., in 92% of the total number of patients or in all patients who were interviewed. Life-long occupational and environmental histories were also obtained from two other categories of patients with Paget's disease: From a small number of females with this disease and from affected relatives of patients with Paget's disease. Paget's disease in family members has been reported by others to be linked to genetic factors. The histories of the small number of these two categories of patients with Paget's disease; the females and the family members, revealed occupational or environmental exposure to a toxic substance, primarily to lead, in the past. This presentation also hypothesizes that lead-exposure is the basis for hyperparathyroidism, which coexists in patients with Paget's disease of bone. It also deals with the attempted correlation of lead contamination in different areas and the prevalence of Paget's disease. 83 refs., 1 fig., 1 tab.

• OSTI ID: 7065884
• Journal Information: Environment International; (United States), Journal Name: Environment International; (United States) Vol. 20:5; ISSN ENVIDV; ISSN 0160-4120
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
DISEASES
ELEMENTS
ENDOCRINE DISEASES
ENVIRONMENTAL EXPOSURE
HYPERPARATHYROIDISM
LEAD
MAMMALS
MAN
METALS
OCCUPATIONAL EXPOSURE
PRIMATES
SKELETAL DISEASES
VERTEBRATES