Potentiation by caffeine of potentially lethal fast-neutron damage in cultured human cells
Journal Article
·
· Radiat. Res.; (United States)
Caffeine was found to potentiate single-dose fast-neutron-induced killing of human T-1 cells when present at 2 mM for 60 hr or more after (and 10 hr before) irradiation. Analyses of survival curves of cells treated with neutrons or X rays with and without caffeine indicate that only the linear, low-dose portion of survival curves is modified. Potentiation of lethality by caffeine is attributed mainly to its effects on single-hit potentially lethal lesions, possibly certain DNA double-strand breaks.
- Research Organization:
- Pennsylvania State Univ., University Park
- OSTI ID:
- 7064683
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 84:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
DNA damage and mammalian cell killing
Effects of caffeine on the expression of potentialy lethal and sublethal damage in. gamma. -irradiated cultured mammalian cells. [Human T-1 cells and Chinese hamster V79-79 cells]
Action of caffeine on x-irradiated HeLa cells. V. Identity of the sector of cells that expresses potentially lethal damage in G/sub 1/ and G/sub 2/
Conference
·
Sat Dec 31 23:00:00 EST 1977
·
OSTI ID:6755307
Effects of caffeine on the expression of potentialy lethal and sublethal damage in. gamma. -irradiated cultured mammalian cells. [Human T-1 cells and Chinese hamster V79-79 cells]
Journal Article
·
Tue May 01 00:00:00 EDT 1979
· Radiat. Res.; (United States)
·
OSTI ID:6221288
Action of caffeine on x-irradiated HeLa cells. V. Identity of the sector of cells that expresses potentially lethal damage in G/sub 1/ and G/sub 2/
Journal Article
·
Thu Jul 01 00:00:00 EDT 1982
· Radiat. Res.; (United States)
·
OSTI ID:6709008
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL CELLS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CAFFEINE
CELL CULTURES
CELL KILLING
COBALT 60
COBALT ISOTOPES
DNA
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
GAMMA RADIATION
HADRONS
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NEUTRONS
NUCLEI
NUCLEIC ACIDS
NUCLEONS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
SIDE EFFECTS
STRAND BREAKS
SURVIVAL CURVES
SYNERGISM
X RADIATION
XANTHINES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL CELLS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CAFFEINE
CELL CULTURES
CELL KILLING
COBALT 60
COBALT ISOTOPES
DNA
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
GAMMA RADIATION
HADRONS
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NEUTRONS
NUCLEI
NUCLEIC ACIDS
NUCLEONS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
SIDE EFFECTS
STRAND BREAKS
SURVIVAL CURVES
SYNERGISM
X RADIATION
XANTHINES
YEARS LIVING RADIOISOTOPES