DNA damage and mammalian cell killing

Conference · Sun Jan 01 04:00:00 EST 1978

OSTI ID:6755307

Elkind, M M

DNA lesions--particularly single- and double-strand breaks--are induced in considerable excess by doses required to register one lethal hit. In the case of x-ray cell killing, the disposition of such damage has been determined in the progeny of surviving cells. Fewer than 0.2% of the single- and 6.0% of the double-strand breaks are propagated. Hence, it is likely that in surviving cells all breaks are repaired. A mechanism of x-ray cell killing based upon misrepair of DNA breaks is proposed.

• Research Organization: Argonne National Lab., Ill. (USA)
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 6755307
• Report Number(s): CONF-780226-9
• Country of Publication: United States
• Language: English

Related Subjects

560114 -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BROMOURACILS
BUDR
CELL KILLING
COMPARATIVE EVALUATIONS
DNA
DRUGS
ELECTROMAGNETIC RADIATION
ERRORS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
RIBOSIDES
STRAND BREAKS
ULTRAVIOLET RADIATION
URACILS
VISIBLE RADIATION
X RADIATION