Metronidazole in the treatment of cervical cancer using Cf-252 neutron brachytherapy

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Nucl. Sci. Appl.; (United States)

OSTI ID:7063803

Maruyama, Y

Metronidazole was tested for its possible use in the Cf-252 brachytherapy of cervical cancer as a radiosensitizer and to deal with anaerobic pelvic infection. 15 patients were treated by only 14 were evaluable. All stages from stage IB-IVB were treated and complete local tumor regression was noted in all cases although it could take place very slowly. 5/14 (36%) are 1.5-3 year survivors but only among the patients with stage I-II disease. No unusual radio-enhancing action was observed but metronidazole appeared to be useful to treat the vaginal, cervix and uterine infections often associated with high stage disease and bulky, ulcerative or necrotic tumors.

• Research Organization: Dept. of Radiation Medicine, Radiation Therapy Oncology Center, Univ. of Kentucky Medical Center, Lexington, KY 40536
• OSTI ID: 7063803
• Journal Information: Nucl. Sci. Appl.; (United States), Vol. 2:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CALIFORNIUM 252
THERAPEUTIC USES
METRONIDAZOLE
NEOPLASMS
NEUTRON THERAPY
UTERUS
ANAEROBIC CONDITIONS
INFECTIVITY
NECROSIS
PATIENTS
PELVIS
RADIOSENSITIZERS
SURVIVAL TIME
ULCERS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALCOHOLS
ALPHA DECAY RADIOISOTOPES
ANTINEOPLASTIC DRUGS
AZOLES
BODY
BODY AREAS
CALIFORNIUM ISOTOPES
DISEASES
DRUGS
EVEN-EVEN NUCLEI
FEMALE GENITALS
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIDAZOLES
ISOTOPES
MEDICINE
NITRO COMPOUNDS
NUCLEAR MEDICINE
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
THERAPY
USES
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)