Treatment of bulky stage IB and IIB cervical cancers with outpatient neutron brachytherapy, external pelvic radiation and extrafascial hysterectomy

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Nucl. Sci. Appl.; (United States)

OSTI ID:7063877

Van Nagell, J R; Maruyama, Y; Yoneda, J; Donaldson, E S; Hanson, M B; Gallion, H H; Powell, D E; Kryscio, R J

From January, 1977, to December, 1982, twenty-nine patients with bulky (>4 cms diameter) Stage IB or IIB cervical cancer were treated at the University of Kentucky Medical Center by a combination of out-patient neutron brachytherapy (Cf-252) and external pelvic radiation followed by extrafascial hysterectomy. Residual tumor was present in the hysterectomy specimens of 25 per cent. Complications during and following radiation therapy and surgery were minimal and included vaginal stenosis, proctitis, and hemorrhagic cystitis. The mean duration of hospitalization for surgery in these patients was 6.6 days (range 5-15 days) and postoperative morbidity was low. No patient required blood transfusion. Four patients developed urinary tract infections and two had superficial wound separations. Following treatment, patients were seen at monthly intervals for one year, every three months for two years, and every six months thereafter. No patient has been lost to follow-up. Two patients (7 per cent) developed tumor recurrence and have died of disease (1 of distant metastases; 1 local). The remaining 27 patients (93 per cent) are alive and well with no evidence of disease 24-89 months (mean 48 months) after therapy. No radiogenic fistulae or bowel obstruction were observed. These preliminary results suggest that the combination of outpatient neutron brachytherapy, external pelvic radiation, and extrafascial hysterectomy for patients with Stage IB and IIB cervical cancer is well tolerated. Complications associated with this treatment regimen have been minimal, and the recurrence rate is low. The duration of intracavitary neutron brachytherapy was short, and outpatient therapy was well received by patients.

• Research Organization: Div. of Gynecologic Oncology, Univ. of Kentucky Medical Center, Lexington, KY 40536
• OSTI ID: 7063877
• Journal Information: Nucl. Sci. Appl.; (United States), Journal Name: Nucl. Sci. Appl.; (United States) Vol. 2:3; ISSN NSAPD
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
BODY
BODY AREAS
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
DIGESTIVE SYSTEM DISEASES
DISEASE INCIDENCE
DISEASES
EVEN-EVEN NUCLEI
FEMALE GENITALS
HEAVY NUCLEI
ISOTOPES
MEDICAL ESTABLISHMENTS
MEDICINE
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ORGANS
PATIENTS
PELVIS
PROCTITIS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SURGERY
THERAPEUTIC USES
THERAPY
USES
UTERUS
YEARS LIVING RADIOISOTOPES