Morbidity and survival patterns in patients after radical hysterectomy and postoperative adjuvant pelvic radiotherapy

Journal Article · Wed Feb 28 23:00:00 EST 1990 · Gynecologic Oncology; (USA)

DOI:https://doi.org/10.1016/0090-8258(90)90139-C· OSTI ID:6834754

Fiorica, J V; Roberts, W S; Greenberg, H; Hoffman, M S; LaPolla, J P; Cavanagh, D ^[1]

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1. Univ.ersity of South Florida College of Medicine, Tampa (USA)

Morbidity and survival patterns were reviewed in 50 patients who underwent radical hysterectomy, pelvic lymphadenectomy, and adjuvant postoperative pelvic radiotherapy for invasive cervical cancer. Ninety percent of the patients were FIGO stage IB, and 10% were clinical stage IIA or IIB. Indications for adjuvant radiotherapy included pelvic lymph node metastasis, large volume, deep stromal penetration, lower uterine segment involvement, or capillary space involvement. Seventy-two percent of the patients had multiple high-risk factors. An average of 4700 cGy of whole-pelvis radiotherapy was administered. Ten percent of the patients suffered major gastrointestinal complications, 14% minor gastrointestinal morbidity, 12% minor genitourinary complications, one patient a lymphocyst, and one patient lymphedema. Of the five patients with major gastrointestinal morbidity, all occurred within 12 months of treatment. Three patients required intestinal bypass surgery for distal ileal obstructions and all are currently doing well and free of disease. All of the patients who developed recurrent disease had multiple, high-risk factors. The median time of recurrence was 12 months. All patients recurred within the radiated field. Actuarial survival was 90% and disease-free survival 87% at 70 months. It is our opinion that the morbidity of postoperative pelvic radiotherapy is acceptable, and benefit may be gained in such a high-risk patient population.

• OSTI ID: 6834754
• Journal Information: Gynecologic Oncology; (USA), Journal Name: Gynecologic Oncology; (USA) Vol. 36:3; ISSN GYNOA; ISSN 0090-8258
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
FEMALE GENITALS
INJURIES
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
POST-IRRADIATION EXAMINATION
PRIMATES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURGERY
SURVIVAL CURVES
THERAPY
UTERUS
VERTEBRATES