Five-year cure of cervical cancer treated using californium-252 neutron brachytherapy

Journal Article · Mon Oct 01 04:00:00 EDT 1984 · Am. J. Clin. Oncol.; (United States)

DOI:https://doi.org/10.1097/00000421-198410000-00018· OSTI ID:5998031

Maruyama, Y; van Nagell, J R; Yoneda, J; Donaldson, E; Hanson, M; Martin, A; Wilson, L C; Coffey, C W; Feola, J; Beach, J L

Female pelvic carcinoma is one of the common malignancies seen at the University of Kentucky Medical Center and often presents in an advanced stage. In 1976, the authors began to test californium-252 neutron brachytherapy (NT) for its efficacy for control of primary and recurrent advanced uterine, cervix, and vaginal cancers. The first protocol used was 5000-5500 rad of whole pelvis irradiation followed by 1-2 Cf-252 insertions using a single tandem placed in the utero-cervico-vaginal region. Of 27 patients with primary carcinomas treated, 10 are alive and well 5 year later (37%). Two of two recurrent tumors were locally controlled but failed later. These patients had advanced cervical, vaginal, or endometrial carcinomas. In 1977, a transitional year, treatment of only unfavorable stages and presentations with NT was initiated. Similar results were obtained with NT as compared to conventional photon therapy (PT). Further improvement in treatment results can be anticipated as NT brachytherapy is used for advanced cancer therapy by more effective treatment schedules and radiation doses. Cf-252 can be used as a radium substitute and achieved similar rates of tumor control and 5-year survivals. 21 references, 2 tables.

• Research Organization: Univ. of Kentucky Medical Center, Lexington
• OSTI ID: 5998031
• Journal Information: Am. J. Clin. Oncol.; (United States), Journal Name: Am. J. Clin. Oncol.; (United States) Vol. 7; ISSN AJCOD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
BODY
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CARCINOMAS
DISEASES
DOSES
EVEN-EVEN NUCLEI
FEMALE GENITALS
HEAVY NUCLEI
ISOTOPES
MEDICINE
NEOPLASMS
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SURVIVAL TIME
THERAPY
UTERUS
YEARS LIVING RADIOISOTOPES