Clinical trial for advanced cervico-vaginal pelvic carcinomas using californium CF-252 fast neutron therapy: report of early responses
This report summarizes clinical experiences with californium (Cf) 252 for the radiotherapy of advanced cervico-vaginal carcinomas at the University of Kentucky Medical Center from November 1976 to April 1979. Fifty-nine patients were treated with Cf-252 during this period. After pilot studies, a treatment schedule was developed which appeared to offer improved local control and clearance of these tumors in approx. 90% of treated patients. Ultimate long term survival and outcome will depend upon the frequency of control of local-regional disease and the frequency of appearance of more disseminated and metastatic disease. Cf-252 neutron brachytherapy was combined with 4500 to 5500 rad of Cobalt 60 or linear accelerator external beam fractionated radiotherapy for 4 to 6 weeks. Neutron treated patients whose disease was in appropriate clinical stages were also treated with combined radiotherapy-surgery without problems. All histological patterns responded, and no unusual severe or unanticipated early side effects or toxic tissue reactions were observed.
- Research Organization:
- Univ. of Kentucky Medical Center, Lexington
- OSTI ID:
- 6680995
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:12
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ABSCESSES
RADIOINDUCTION
BLADDER
EARLY RADIATION EFFECTS
CALIFORNIUM 252
RADIATION SOURCE IMPLANTS
FAST NEUTRONS
RBE
FEMALE GENITALS
FISTULAE
RADIOTHERAPY
SIDE EFFECTS
CARCINOMAS
COBALT 60
FRACTIONATED IRRADIATION
GAMMA RADIATION
LINEAR ACCELERATORS
LOW DOSE IRRADIATION
OXYGEN ENHANCEMENT RATIO
PATIENTS
ACCELERATORS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CALIFORNIUM ISOTOPES
COBALT ISOTOPES
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EVEN-EVEN NUCLEI
FERMIONS
HADRONS
HEAVY NUCLEI
IMPLANTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION SOURCES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
THERAPY
URINARY TRACT
YEARS LIVING RADIOISOTOPES
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)