Diffusion-weighted MR imaging of acute stroke: Correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats

Journal Article · Tue May 01 04:00:00 EDT 1990 · AJNR, American Journal of Neuroradiology; (USA)

OSTI ID:7063667

Moseley, M E; Kucharczyk, J; Mintorovitch, J; Cohen, Y; Kurhanewicz, J; Derugin, N; Asgari, H; Norman, D ^[1]

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1. Univ. of California, San Francisco (USA)

We evaluated the temporal and anatomic relationships between changes in diffusion-weighted MR image signal intensity, induced by unilateral occlusion of the middle cerebral artery in cats, and tissue perfusion deficits observed in the same animals on T2-weighted MR images after administration of a nonionic intravascular T2 shortening agent. Diffusion-weighted images obtained with strong diffusion-sensitizing gradient strengths (5.6 gauss/cm, corresponding to gradient attenuation factor, b, values of 1413 sec/mm2) displayed increased signal intensity in the ischemic middle cerebral artery territory less than 1 hr after occlusion, whereas T2-weighted images without contrast usually failed to detect injury for 2-3 hr after stroke. After contrast administration (0.5-1.0 mmol/kg by Dy-DTPA-BMA, IV), however, T2-weighted images revealed perfusion deficits (relative hyperintensity) within 1 hr after middle cerebral artery occlusion that corresponded closely to the anatomic regions of ischemic injury shown on diffusion-weighted MR images. Close correlations were also found between early increases in diffusion-weighted MR image signal intensity and disrupted phosphorus-31 and proton metabolite levels evaluated with surface coil MR spectroscopy, as well as with postmortem histopathology. These data indicate that diffusion-weighted MR images more accurately reflect early-onset pathophysiologic changes induced by acute cerebral ischemia than do T2-weighted spin-echo images.

• OSTI ID: 7063667
• Journal Information: AJNR, American Journal of Neuroradiology; (USA), Journal Name: AJNR, American Journal of Neuroradiology; (USA) Vol. 11:3; ISSN 0195-6108; ISSN AAJND
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BARYONS
BODY
BRAIN
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CATS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
COMPARATIVE EVALUATIONS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
DTPA
ELEMENTARY PARTICLES
ELEMENTS
FERMIONS
HADRONS
ISCHEMIA
MAGNETIC RESONANCE
MAMMALS
NERVOUS SYSTEM
NMR IMAGING
NONMETALS
NUCLEAR MAGNETIC RESONANCE
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
PERFUSED TISSUES
PHOSPHORUS
PROTONS
RADIOPROTECTIVE SUBSTANCES
RESONANCE
SPIN ECHO
TISSUES
VASCULAR DISEASES
VERTEBRATES