Serial magnetic resonance imaging of evolving focal cerebral ischemia in the CAT
Magnetic resonance imaging (MRI) is recognized as a sensitive medium for detecting lesions within the central nervous system. Three cats were scanned under light pentobarbital anesthesia using various MRI techniques before and after right middle cerebral artery (MCA) occlusion. Scanning began as early as four minutes after MCA occlusion and continued 8 to 10 hours. The animals were subsequently perfused with a colloidal carbon and phosphate buffered formalin. Brains were removed and sliced for histopathologic examination. The sharpest images were produced with a single spin-echo, multi-slice technique using a 0.6 Tesla (T) FIELD, 0.4 cm slice thickness, and a surface coil. Changes were apparent within 1 hr after MCA occlusion with T2 weighting (TR 2000 msec, TE 120 msec). Increased signal with this technique correlated with areas of decreased colloidal carbon perfusion. One animal with a large cortical infarction showed increased cortical signal at the time of the first MRI scan completed in the first 20 min. An animal with only mild cortical changes and severe ischemic changes in the dorsal thalamus nuclei had similar MRI results. T1 weighted images (TR 500 msec, TE 30 msec) revealed changes in hemispheric contour possibly corresponding to edema at 4 hours post occlusion. One animal imaged with almost double the slice thickness (0.75 cm) and with a 1.5 T field showed poor image quality using the above techniques but without a surface coil. MRI is sensitive in detecting changes due to cerebral ischemia within 30 minutes of onset. Increased MRI signal correlated with areas of decreased colloidal carbon perfusion, demonstrated at later times.
- Research Organization:
- Cleveland Clinic Foundation, Cleveland, OH
- OSTI ID:
- 6638346
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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CEREBRUM
ISCHEMIA
NMR IMAGING
FORMALDEHYDE
INFUSION
DIAGNOSIS
IMAGES
ARTERIES
BUFFERS
CARBON COMPOUNDS
CATS
CEREBRAL CORTEX
COLLOIDS
DETECTION
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
EDEMA
HISTOLOGY
IMAGE PROCESSING
PHOSPHATES
SENSITIVITY
ALDEHYDES
ANIMALS
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DISEASES
DISPERSIONS
INTAKE
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHOSPHORUS COMPOUNDS
PROCESSING
SYMPTOMS
USES
VASCULAR DISEASES
VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)