Potentially-lethal damage and radioprotection in human cells exposed to californium-252

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Nucl. Sci. Appl.; (United States)

OSTI ID:7062985

Schroy, C B; Goud, S N; Magura, C; Feola, J M; Maruyama, Y

Cultured human T-1E cells were irradiated with californium-252 neutrons and gamma rays. When 2 mm caffeine was present in the medium for 47 h after irradiation cell survival (assayed by colony formation) was decreased significantly. When 2 m dimethylsulfoxide was present during the irradiations radioprotection was observed using the same assay. The caffeine data indicate that potentially-lethal lesions exist in cells after californium exposure and that these lesions can be made lethal when they would otherwise be repaired. The DMSO data indicate that radioprotection from californium exposure can be achieved and that scanvengable free radicals play an important role in Cf-252 lethality.

• Research Organization: Cleveland Clinic Foundation, Dept. of Radiation Therapy, Cleveland, OH
• OSTI ID: 7062985
• Journal Information: Nucl. Sci. Appl.; (United States), Journal Name: Nucl. Sci. Appl.; (United States) Vol. 2:3; ISSN NSAPD
• Country of Publication: United States
• Language: English

Related Subjects

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANALEPTICS
ANIMAL CELLS
AROMATICS
AZAARENES
BIOASSAY
CAFFEINE
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CELL CULTURES
CENTRAL NERVOUS SYSTEM AGENTS
DATA ANALYSIS
DMSO
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EMISSION
EVEN-EVEN NUCLEI
GAMMA RADIATION
HAZARDS
HEALTH HAZARDS
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HUMAN POPULATIONS
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LETHAL DOSES
LETHAL IRRADIATION
NEUTRON EMISSION
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHOTON EMISSION
POPULATIONS
PURINES
RADIATION HAZARDS
RADIATION PROTECTION
RADIATIONS
RADICALS
RADIOISOTOPES
SULFOXIDES
SURVIVAL TIME
XANTHINES
YEARS LIVING RADIOISOTOPES