Micronuclei in bone marrow cells of BALB/c mice irradiated with Cf-252 or Co-60

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Nucl. Sci. Appl.; (United States)

OSTI ID:7062697

Goud, S N; Feola, J M; Maruyama, Y

In the present investigation, Cf-252, a mixed neutron and gamma emitter, was studied using a simple and sensitive assay called the micronucleus (MN) test. The mice were exposed to whole body radiation from Cf-252 (10-60 cGy) or Co-60 (20-120 cGy) and scored for the presence of micronuclei in polychromatic erythrocytes (PCE) 24 hours after irradiation. The results indicate the relative biological effectiveness (RBE) of Cf-252 to be 2.1 compared to Co-60 gamma rays. When only the neutron component was considered the RBE/sub n/ was 2.6.

• Research Organization: Dept. of Radiation Medicine, Univ. of Kentucky Medical Center, Lexington, KY
• OSTI ID: 7062697
• Journal Information: Nucl. Sci. Appl.; (United States), Journal Name: Nucl. Sci. Appl.; (United States) Vol. 2:3; ISSN NSAPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
560162 -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
CELL CONSTITUENTS
CELL NUCLEI
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
EMISSION
ERYTHROCYTES
EVEN-EVEN NUCLEI
EXTERNAL IRRADIATION
GAMMA RADIATION
HEAVY NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MICE
MINUTES LIVING RADIOISOTOPES
NEUTRON EMISSION
NUCLEI
ODD-ODD NUCLEI
PHOTON EMISSION
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RBE
RODENTS
SOMATIC CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES