AET reduces the frequency of micronuclei in bone marrow cells of mice exposed to. gamma. radiation
Journal Article
·
· Radiat. Res.; (United States)
The purpose of this paper was to determine whether or not a radioprotective agent which binds to DNA and inhibits DNA damage could also provide protection against radiation-induced micronuclei. Male mice were injected intraperitoneally with such an agent, 2-aminoethylisothiouronium bromide hydrobromide (AET), or its solvent 15 min prior to a single 10-min exposure to /sup 60/Co ..gamma.. rays delivered at various dose rates. Animals were killed 24 hr after irradiation and examined for the frequency of polychromatic erythrocytes containing micronuclei. The results showed a significant dose response to the irradiation for both treatments and a significant reduction in the frequency of micronucleated cells in the mice receiving the radioprotective agent.
- Research Organization:
- Argonne National Lab., IL
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 5681943
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 93:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
AET reduces the frequency of micronuclei in bone marrow cells of mice exposed to gamma radiation
TOXICITY AND TOLERANCE STUDIES ON AET
DNA content determination of micronucleated polychromatic erythrocytes induced by clastogens and spindle poisons in mouse bone marrow and peripheral blood
Journal Article
·
Fri Dec 31 23:00:00 EST 1982
· Radiat. Res.; (United States)
·
OSTI ID:5992156
TOXICITY AND TOLERANCE STUDIES ON AET
Journal Article
·
Sun Mar 31 23:00:00 EST 1963
· Arch. Intern. Pharmacodyn.
·
OSTI ID:4664667
DNA content determination of micronucleated polychromatic erythrocytes induced by clastogens and spindle poisons in mouse bone marrow and peripheral blood
Conference
·
Thu Dec 31 23:00:00 EST 1992
· Cytometry (Baltimore); (United States)
·
OSTI ID:6831587
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AET
AMINES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CARBONIC ACID DERIVATIVES
CELL CONSTITUENTS
CELL NUCLEI
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DNA
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
ERYTHROCYTES
GAMMA RADIATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTRAPERITONEAL INJECTION
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
THIOUREAS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AET
AMINES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CARBONIC ACID DERIVATIVES
CELL CONSTITUENTS
CELL NUCLEI
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DNA
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
ERYTHROCYTES
GAMMA RADIATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTRAPERITONEAL INJECTION
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
THIOUREAS
VERTEBRATES
YEARS LIVING RADIOISOTOPES