Cf-252 leukemogenesis in the C57BL mouse

Journal Article · Thu Jan 01 04:00:00 EST 1987 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(87)90262-8· OSTI ID:6694225

Feola, J M; Maruyama, Y; Pattarasumunt, A; Kryscio, R M

Radiation-induced leukemia/lymphomas were induced in C57BL mice using four weekly acute /sup 60/Co fractionated irradiation exposures (to 188 cGy, or graded doses of low dose rate (LDR) Cf-252 irradiation given in fractionated exposure sessions at four weekly intervals. The acute /sup 60/Co radiation produced 84% thymic lymphomas with a median survival time (MST) of 162 days for mice developing tumors. Mice were exposed to Cf-252 n + gamma radiation in graded doses of 50, 62.5, 80, 112, and 188 cGy per week repeated 4X. Mice exposed to Cf-252 radiation developed thymic lymphomas on a much delayed time schedule. Mice irradiated at 50-80 cGy Cf-252 were killed after the /sup 60/Co induced thymoma mice had died to detect tumors. At Cf-252 doses of 112 or 188 rads 79 or 70% of mice, respectively, developed thymic lymphomas and had similar survival times which gave an estimated leukemogenesis RBEn of approximately 1.0-2.0. These studies show that for Cf-252 n + gamma radiation, compared to /sup 60/Co for leukemogenic efficiency, had a much longer latent period, and had a low RBE (1.0-2.0) at the large doses per fraction used in these studies. Under the experimental fractionated conditions tested, Cf-252 neutrons were leukemogenic, but only slightly more so than fractionated /sup 60/Co.

• Research Organization: Univ. of Kentucky Medical Center, Lexington
• OSTI ID: 6694225
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 1; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CALIFORNIUM 252
CALIFORNIUM ISOTOPES
COBALT 60
COBALT ISOTOPES
DISEASES
EVEN-EVEN NUCLEI
FRACTIONATED IRRADIATION
HEAVY NUCLEI
HEMIC DISEASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKEMIA
LYMPHOMAS
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
RADIOINDUCTION
RADIOISOTOPES
RBE
RODENTS
SURVIVAL TIME
VERTEBRATES
YEARS LIVING RADIOISOTOPES