Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: correlation with vitamin E content. [Rats, rabbits, mice, human]

Journal Article · Tue Jan 01 00:00:00 EST 1980 · Lipids; (United States)

OSTI ID:7060420

Kornbrust, D J; Mavis, R D

Rates of in vitro lipid peroxidation of microsomes and homogenates were found to vary widely among different tissues and species. In rats and rabbits, lung microsomes peroxidized at 25- to 50-fold lower rate than liver, kidney, testes and brain microsomes. Heart microsomes peroxidized at a rate slightly greater than, but most similar to, lung microsomes. Comparison of tissue homogenates also revealed the unique resistance of lung and heart to lipid peroxidation. Higher rates of peroxidation in mouse lung microsomes relative to rabbit, rat and human lung microsomes were similarly correlated with a lower ratio of vitamin E to peroxidizable fatty acids in mouse lung microsomes. These data provide strong support for the role of vitamin E as the major cellular antioxidant, especially in the highly oxygenated tissues of heart and lung, and demonstrate the utility of the microsomal system in characterizing tissue differences in susceptibility to peroxidative membrane decomposition.

• Research Organization: Univ. of Rochester, NY
• OSTI ID: 7060420
• Journal Information: Lipids; (United States), Vol. 15:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BRAIN
ENZYME ACTIVITY
HEART
ANTIOXIDANTS
HOMOGENATES
COMPARATIVE EVALUATIONS
KIDNEYS
LIPIDS
PEROXIDASES
LIVER
LUNGS
MICROSOMES
TESTES
IN VITRO
LIPOSOMES
VITAMIN E
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
ENZYMES
GLANDS
GONADS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MALE GENITALS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
PORPHYRINS
RESPIRATORY SYSTEM
VITAMINS
550200* - Biochemistry