T cells from fully H-2 allogeneic (A replaced by B) radiation bone marrow chimeras are functionally competent and host restricted but are alloreactive against hybrid Ia determinants expressed on (A x B)F1 cells
Journal Article
·
· J. Exp. Med.; (United States)
In this communication it is demonstrated that T cells from fully allogeneic A replaced by B radiation bone marrow chimeras are alloreactive against the hybrid Ia molecules expressed on the surface of heterozygous A X B cells. These results suggested that previous failures to generate cytotoxic T lymphocyte (CTL) responses from fully allogeneic chimeras by sensitizing the chimeric T cells to antigen in an (A X B)F1-priming environment might have been confounded by an ongoing alloreaction against determinants created by hybrid Ia molecules expressed on F1 cells. Consequently, the ability to generate CTL responses from fully allogeneic chimeras was re-examined by sensitizing the chimeric T cells to antigen presented by homozygous rather that F1 stimulator cells. It was found that T cells of donor bone marrow origin that mediate cytotoxic responses to trinitrophenyl-modified self determinants do differentiate into functional competence in an H-2-incompatible host environment and are restricted to the host H-2 haplotype.
- Research Organization:
- Immunology Branch, National Cancer Institute, Bethesda, Maryland
- OSTI ID:
- 7054544
- Journal Information:
- J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 155:6; ISSN JEMEA
- Country of Publication:
- United States
- Language:
- English
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Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells
Journal Article
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Mon Dec 31 23:00:00 EST 1979
· J. Immunol.; (United States)
·
OSTI ID:5629657
Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development
Journal Article
·
Wed Dec 31 23:00:00 EST 1980
· J. Exp. Med.; (United States)
·
OSTI ID:6058819
Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells
Journal Article
·
Tue Nov 30 23:00:00 EST 1982
· J. Exp. Med.; (United States)
·
OSTI ID:5984646
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CHIMERAS
CONNECTIVE TISSUE CELLS
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MOSAICISM
ORGANS
RADIATION CHIMERAS
RADIATION EFFECTS
SOMATIC CELLS
TISSUES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANTIGEN-ANTIBODY REACTIONS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CHIMERAS
CONNECTIVE TISSUE CELLS
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MOSAICISM
ORGANS
RADIATION CHIMERAS
RADIATION EFFECTS
SOMATIC CELLS
TISSUES