Allogeneic radiation chimeras respond to TNP-modified donor and host targets
Tolerance to major histocompatibility antigens as well as the ability to mount a cytotoxic response to hapten-modified cells of bone marrow donor and host origin was studied in allogeneic radiation chimeras. Lethally irradiated (C57BL/6 x DBA/2)F1 hosts reconstituted with anti-Thy 1.2 + C-treated bone marrow from (C57BL/6 x CBA)F1 mice showed tolerance to the MHC antigens of the three parental strains as measured by MLC and CML assay. The chimeras responded normally to unrelated allogeneic cells. Chimeric animals generated a cytotoxic response to hapten-modified cells of both donor (CBA) and host (DBA/2) haplotypes, as well as to C57BL/6, demonstrating that tolerance to the hapten-presenting host haplotype is sufficient to allow a cytotoxic antihapten response, and that processing through a semiallogeneic host environment does not affect the ability to generate a response to hapten in conjunction with self-determinants. Chimeras failed to mount a cytotoxic response to hapten presented on nontolerated allogeneic spleen cells.
- Research Organization:
- Memorial Sloan-Kettering Inst., New York, NY
- OSTI ID:
- 5629657
- Journal Information:
- J. Immunol.; (United States), Vol. 124:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
RADIATION CHIMERAS
GRAFT-HOST REACTION
BONE MARROW
CYTOLOGY
IMMUNE REACTIONS
IMMUNITY
IMMUNOLOGY
TOXICITY
TRANSPLANTS
ANIMAL TISSUES
BIOLOGY
BODY
CHIMERAS
HEMATOPOIETIC SYSTEM
MOSAICISM
ORGANS
TISSUES
560122* - Radiation Effects on Cells- Internal Source- (-1987)
560152 - Radiation Effects on Animals- Animals