Allogeneic radiation chimeras respond to TNP-modified donor and host targets

Journal Article · Mon Dec 31 23:00:00 EST 1979 · J. Immunol.; (United States)

OSTI ID:5629657

Lattime, E C; Gershon, H E; Stutman, O

Tolerance to major histocompatibility antigens as well as the ability to mount a cytotoxic response to hapten-modified cells of bone marrow donor and host origin was studied in allogeneic radiation chimeras. Lethally irradiated (C57BL/6 x DBA/2)F1 hosts reconstituted with anti-Thy 1.2 + C-treated bone marrow from (C57BL/6 x CBA)F1 mice showed tolerance to the MHC antigens of the three parental strains as measured by MLC and CML assay. The chimeras responded normally to unrelated allogeneic cells. Chimeric animals generated a cytotoxic response to hapten-modified cells of both donor (CBA) and host (DBA/2) haplotypes, as well as to C57BL/6, demonstrating that tolerance to the hapten-presenting host haplotype is sufficient to allow a cytotoxic antihapten response, and that processing through a semiallogeneic host environment does not affect the ability to generate a response to hapten in conjunction with self-determinants. Chimeras failed to mount a cytotoxic response to hapten presented on nontolerated allogeneic spleen cells.

• Research Organization: Memorial Sloan-Kettering Inst., New York, NY
• OSTI ID: 5629657
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 124:1; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

560122* -- Radiation Effects on Cells-- Internal Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BIOLOGY
BODY
BONE MARROW
CHIMERAS
CYTOLOGY
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
IMMUNITY
IMMUNOLOGY
MOSAICISM
ORGANS
RADIATION CHIMERAS
TISSUES
TOXICITY
TRANSPLANTS