Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development
Journal Article
·
· J. Exp. Med.; (United States)
In this study the cytotoxic T lymphocyte (CTL) recognition pattern of thymocytes from recently reconstituted parent leads to F1 and F1 leads to parent radiation bone marrow chimeras was investigated. Chimeric thymocytes were entirely of donor origin approximately 4 weeks after irradiation and reconstitution but were not capable of autonomously generating either alloreactive or trinitrophenyl (TNP)-modified-self-reactive CTL responses. These experiments demonstrte that even at the earliest time CTL effectors of donor origin from the thymuses of chimeras can be studied, their self-receptor repertoire has already been restricted to recognition of host MHC determinants. These results support the cocept that the host environment influences the self-recognition capacity of T cells at the pre- or intrathymic stage of differentation.
- OSTI ID:
- 6058819
- Journal Information:
- J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 153:1; ISSN JEMEA
- Country of Publication:
- United States
- Language:
- English
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Journal Article
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Mon Jun 01 00:00:00 EDT 1981
· J. Exp. Med.; (United States)
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OSTI ID:5736758
Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells
Journal Article
·
Tue Nov 30 23:00:00 EST 1982
· J. Exp. Med.; (United States)
·
OSTI ID:5984646
Self-recognition specificity expressed by T cells from nude mice. Absence of detectable Ia-restricted T cells in nude mice that do exhibit self-K/D-restricted T cell responses
Journal Article
·
Sat Sep 01 00:00:00 EDT 1984
· J. Exp. Med.; (United States)
·
OSTI ID:6268228
Related Subjects
550300* -- Cytology
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
IMMUNITY
IMMUNOLOGY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MOSAICISM
RADIATION CHIMERAS
RADIATION EFFECTS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
THYMOCYTES
VERTEBRATES
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
IMMUNITY
IMMUNOLOGY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MOSAICISM
RADIATION CHIMERAS
RADIATION EFFECTS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
THYMOCYTES
VERTEBRATES