Preclinical toxicologic evaluation of 5-isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro-(nsc 163501), in dogs, monkeys, and cdf1 mice. Final report 24 Apr-13 Sep 78

Technical Report · Fri Nov 10 04:00:00 EST 1978

OSTI ID:7053623

Denine, E P; Stout, L D; Peckham, J C; Guarino, A M; Davis, R D

Dose-limiting gastrointestinal toxicosis was qualitatively similar in dogs, monkeys, and mice. In dogs and monkeys, anorexia and/or oligodipsia were cardinal signs. Severity of intoxication was indicated by progression to a diarrheal syndrome. Intoxication of the erythron was indicated in the dog and monkey studies. Quantitatively, mice were the most resistant to toxicity, and monkeys were more resistant than dogs. In dogs, fractionation of a single dose to five daily doses resulted in marked cumulative toxicity. Further fractionation to 10 daily doses produced only additive intoxication. Fractionation of a single dose to weekly doses offered some protection from additive toxicity. Similar results were obtained when 5 daily doses were fractionated to three 5-day courses of treatment separated by 9-day rest periods.

• Research Organization: Battelle Toxicology Program Office, Vienna, VA (USA)
• OSTI ID: 7053623
• Report Number(s): PB-84-163724
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
BIOASSAY
DOGS
DRUGS
LABORATORY ANIMALS
MAMMALS
MICE
MONKEYS
PATHOLOGY
PRIMATES
RODENTS
TOXICITY
VERTEBRATES