Somatosensory thresholds in monkeys exposed to acrylamide

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(83)90343-5· OSTI ID:6962547

Maurissen, J P.J.; Weiss, B; Davis, H T

Six monkeys were trained to report detection of a vibratory or electrical stimulus applied to the fingertip. The vibratory stimuli were presented at two frequencies (40 and 150 Hz). Thresholds were determined with a tracking procedure before, during, and after dosing. Each monkey served as its own control. Four monkeys were dosed orally with 10 mg/kg of acrylamide 5 days a week until the appearance of toxic signs. The total administered dose varied between 320 and 450 mg/kg. The other two monkeys served as time-matched controls. All the monkeys were observed 5 days a week. They were also weighed and presented with a visuomotor task twice a week. Weight loss usually preceded the onset of gross behavioral disturbances, such as loss of balance, tremor, or decreased activity. Impaired coordination, as revealed with the pickup test, paralleled weight loss. Electrical sensitivity was not affected. Vibration sensitivity, however, fell during dosing and remained impaired for several months after dosing ended. These data indicate that vibration sensitivity testing can trace the time course of intoxication and recovery in toxic peripheral neuropathies. Furthermore, the differential results obtained with vibratory and electrical stimulation are consonant with a primary effect on end-organ receptors.

• Research Organization: Univ. of Rochester School of Medicine and Dentistry, NY
• DOE Contract Number: AC02-76EV03490
• OSTI ID: 6962547
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 71; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRYLAMIDE
AMIDES
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BODY
DISTURBANCES
DOSES
MAMMALS
MONKEYS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRIMATES
RADIATION DOSES
STIMULI
THRESHOLD DOSE
TOXICITY
VERTEBRATES