Comparative response of dogs and monkeys to sublethal acute and continuous low dose-rate gamma-ray exposure

Technical Report · Tue Feb 01 04:00:00 EST 1977

DOI:https://doi.org/10.2172/7312512· OSTI ID:7312512

Spalding, J F; Holland, L M; Johnson, O S; LaBauve, P M; London, J E; Prine, J R; Vigil, E A

Monkeys (Macaca mulatta) and dogs (beagle) were given thirteen 100-rad gamma-ray doses at 28-day intervals. The comparative response (injury and recovery) of the hematopoietic system of the two species was observed at 7-day intervals during the exposure regime. At 84 days after the thirteenth gamma-ray dose, the 1300-rad conditioned and control dogs and monkeys were challenged continuously with 35 R/day until death to determine the amount of radiation-induced injury remaining in conditioned animals as a reduction in mean survival time. Dogs (50 percent) and monkeys (8 percent) died from injury incurred during the conditioning exposures. Thus, the comparative response of dogs and monkeys to dose protraction by acute dose fractionation was similar to what might be expected from a single acute dose. Mean survival times for nonconditioned dogs and monkeys during continuous exposure at 35 R/day were the same (approximately 1400 h). Thus, hematopoietic response of the two species by this method of dose protraction was not significantly different. Mean survival times of conditioned dogs and monkeys during the continuous 35 R/day gamma-ray challenge exposure were greater than for their control counterparts. Thus, the long-term radiation-induced injury was not measurable by this method. Conditioning doses of more than four times the acute LD/sub 50/-/sub 30/ in dogs and approximately two times that of monkeys served only to increase both mean survival time and variance in a gamma-ray stress environment with a dose rate of 35 R/day.

• Research Organization: Los Alamos Scientific Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 7312512
• Report Number(s): LA-6716-MS
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
CHRONIC EXPOSURE
CHRONIC IRRADIATION
COMPARATIVE EVALUATIONS
DOGS
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
DOSES
FRACTIONATED IRRADIATION
GAMMA SOURCES
HEMATOPOIETIC SYSTEM
INJURIES
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MONKEYS
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIATION SOURCES
RECOVERY
TIME DEPENDENCE
VERTEBRATES