Delayed radiation injury of gut-exposed and gut-shielded mice. I. The decrement in resistance to continuous gamma-ray stress
Two mouse strains (RF/J and C57B1/6J) were exposed to x-ray doses totaling 400, 800, or 1200 rad. Total doses were given in 200-rad fractions at 7-day intervals to the whole body, gut only, or gut shielded. Animals treated as above (conditioned) were divided into 2 groups to form a two-part investigation. X-ray-conditioned and control mice were subjected to a continuous gamma-ray stress (challenge exposure) 28 days after the last x-ray dose. Delayed injury was measured as a reduction in mean after-survival (MAS) time and was observed in whole-body, gut-conditioned, and gut-shielded groups. The cause of death was attributed to hemopoietic hypoplasia in all groups. MAS reduction in all conditioned groups in both strains was linear with dose within the dose range used. Delayed injury per volume dose (measured as a reduction in MAS) was independent of the tissue initially conditioned with an acute dose of x rays. Thus, delayed injury per unit weight of gut tissue exposed was equal to that of either whole-body or gut-shielded radiation injury. Comparative weight loss observations during the continuous gamma-ray challenge exposure revealed a decrement in metabolic processes associated with body weight maintenance. This decrement was seen in all x-ray-conditioned groups.
- Research Organization:
- Los Alamos Scientific Lab., NM (USA)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 7292263
- Report Number(s):
- LA-6717-MS
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL VARIABILITY
BODY
CHRONIC EXPOSURE
CHRONIC IRRADIATION
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
DOSE RATES
DOSES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
GENETIC VARIABILITY
HEMATOPOIETIC SYSTEM
INTESTINES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
ORGANS
PATHOLOGICAL CHANGES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RESPONSE MODIFYING FACTORS
RODENTS
SHIELDING
SURVIVAL TIME
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL VARIABILITY
BODY
CHRONIC EXPOSURE
CHRONIC IRRADIATION
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
DOSE RATES
DOSES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
GENETIC VARIABILITY
HEMATOPOIETIC SYSTEM
INTESTINES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
ORGANS
PATHOLOGICAL CHANGES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RESPONSE MODIFYING FACTORS
RODENTS
SHIELDING
SURVIVAL TIME
VERTEBRATES
X RADIATION