Delayed match-to-sample early performance decrement in monkeys after $sup 60$Co irradiation

Journal Article · Tue Jul 01 04:00:00 EDT 1975 · Radiat. Res., v. 63, no. 1, pp. 83-96

OSTI ID:4148145

Bruner, A; Bogo, V; Jones, R K

Sixteen monkeys were trained on a delayed match-to-sample task (DMTS) based on shock avoidance and irradiated with single, whole-body exposures of from 396 to 2000 rad $sup 60$Co (midbody dose) at between 163 and 233 rad/min. Pre- to post-irradiation performance changes were assessed using a penalty-scaling measure which differentially weighted incorrect responses, response omissions, and error-omission sequences. Thirteen of the animals displayed early performance decrement, including five incapacitations, at lower doses (less than 1000 rad) than heretofore found effective. This was considered a function of task complexity, measurement sensitivity, and gamma effectiveness. The minimum effective midbody dose for inducing decrement using the DMTS task was estimated to be on the order of 500 rad. The nature of early, transient performance decrement seems to reflect more of an inability to perform than an inability to perform correctly. (auth)

• Research Organization: Lovelace Foundation, Albuquerque, NM
• NSA Number: NSA-33-007537
• OSTI ID: 4148145
• Journal Information: Radiat. Res., v. 63, no. 1, pp. 83-96, Journal Name: Radiat. Res., v. 63, no. 1, pp. 83-96; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

*ACTINOMYCIN-- RADIOSENSITIVITY EFFECTS
*CHROMOSOME BREAKAGE-- BIOLOGICAL REPAIR
*RADIATION INJURIES-- BIOLOGICAL REPAIR
*SACCHAROMYCES CEREVISIAE-- RADIOSENSITIVITY
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
BIOLOGICAL RADIATION EFFECTS
CELL DIVISION
LETHAL IRRADIATION
MITOSIS
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
X RADIATION