Effect of nitrogen dioxide, ozone, and peroxyacetyl nitrate on metabolic and pulmonary function. Research report, September 1983-October 1986

Technical Report · Tue Mar 31 23:00:00 EST 1987

OSTI ID:7052804

Drechsler-Parks, D M

The report is the first published account of the pulmonary and metabolic effects of oxidant air pollutants on healthy men and women, middle-aged and older, compared with young adults of either gender. Dr. Drechsler-Parks exposed each of 32 subjects to 0.13 ppm peroxyacetyl nitrate, 0.45 ppm ozone, 0.6 ppm nitrogen dioxide and air, plus a combination of two, and then all three, of the oxidant gases. Their responses to the exposures were measured after alternating periods of exercise and rest over a two-hour period. The results of the study were: (1) mixtures of gases did not cause an enhanced effect; (2) pulmonary effects were observed for ozone but not for the other gases; (3) women showed a slightly larger percentage decrement of lung function in response to ozone than did men; and (4) older people (51 to 76 years) may be less responsive to ozone than are younger people (18 to 26 years). The author discusses the significance, limitations, and interpretations of these findings in detail.

• Research Organization: Health Effects Inst., Cambridge, MA (USA)
• OSTI ID: 7052804
• Report Number(s): PB-88-234372/XAB; HEI/RR-87/06
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE GROUPS
AIR POLLUTION
BIOLOGICAL EFFECTS
CHALCOGENIDES
DISEASES
DOCUMENT TYPES
ESTERS
NITRATES
NITRIC ACID ESTERS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC COMPOUNDS
OXIDES
OXIDIZERS
OXYGEN COMPOUNDS
OZONE
PEROXYACETYL NITRATE
POLLUTION
PROGRESS REPORT
RESPIRATION
RESPIRATORY SYSTEM DISEASES