Effect of nitrogen dioxide, ozone, and peroxyacetyl nitrate on metabolic and pulmonary function

Journal Article · Wed Apr 01 04:00:00 EST 1987 · Research Report Health Effects Institue; (USA)

OSTI ID:6714260

Drechsler-Parks, D M ^[1]

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1. Univ. of California, Santa Barbara (USA)

The metabolic and pulmonary function responses were investigated in 32 non-smoking men and women (8 men and 8 women 18-26 years of age, and 8 men and 8 women 51-76 years of age) who were exposed for 2 hours to each of 8 conditions: (1) filtered air (FA), (2) 0.13 ppm peroxyacetyl nitrate (PAN), (3) 0.45 ppm ozone (O3), (4) 0.60 ppm nitrogen dioxide (NO2), (5) 0.13 ppm PAN + 0.45 ppm O3 (PAN/O3), (6) 0.13 ppm PAN + 0.60 ppm NO2 (PAN/NO2), (7) 0.60 ppm NO2 + 0.45 ppm O3 (NO2/O3), and (8) 0.13 ppm PAN + 0.60 ppm NO2 + 0.45 ppm O3 (PAN/NO2/O3). The subjects alternated 20-min periods of rest (n = 3) and cycle ergometer exercise (n = 3) at a work load predetermined to elicit a ventilatory minute volume (VE) of approximately 25 L/min (BTPS). Functional residual capacity (FRC) was determined pre- and post-exposure. Forced vital capacity (FVC) was determined before and after exposure, and 5 min after each exercise period. Heart rate was monitored throughout each exposure, and VE was measured during the last 2 min of each exercise period. Exposure to FA, PAN, NO2, and PAN/NO2 had no effect on any measure of pulmonary or metabolic function. Ozone was primarily responsible for the pulmonary function effects observed. There was no significant difference between the responses to O3 exposure and the responses to the three O3 mixtures, indicating no interactions between the pollutants. The results suggest that women may be somewhat more responsive to O3 exposure than men, and that older people (51-76 years of age) may be less responsive to O3 than younger people (18-26 years of age).

• OSTI ID: 6714260
• Journal Information: Research Report Health Effects Institue; (USA), Journal Name: Research Report Health Effects Institue; (USA) Vol. 6; ISSN RRHIE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETIC ACID
AGE DEPENDENCE
AIR POLLUTION
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHALCOGENIDES
ESTERS
EXERCISE
LUNGS
MAMMALS
MAN
METABOLISM
MONOCARBOXYLIC ACIDS
NITRATES
NITRIC ACID ESTERS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
OZONE
PEROXYACETYL NITRATE
POLLUTION
PRIMATES
RESPIRATION
RESPIRATORY SYSTEM
SEX DEPENDENCE
VERTEBRATES