Effects of peroxyacetyl nitrate alone and in combination with ozone in healthy young women

Journal Article · Fri Feb 28 23:00:00 EST 1986 · J. Air Pollut. Control Assoc.; (United States)

DOI:https://doi.org/10.1080/00022470.1986.10466067· OSTI ID:5801429

Horvath, S M; Bedi, J F; Drechsler-Parks, D M

Metabolic and pulmonary functions were investigated in 10 nonsmoking, young adult women who were exposed for 2 h (21/sup 0/C WBGT) to four conditions: filtered air (FA), 0.27 ppm peroxyacetyl nitrate (PAN), 0.48 ppm ozone (O/sub 3/), and 0.48 ppm O/sub 3/ + 0.27 ppm PAN (PAN/O/sub 3/). The subjects alternated 15-min periods of rest and 20-min periods of bicycle ergometer exercise eliciting a V/sub E/ of 25 L. Functional residual capacity (FRC) was determined pre- and post-exposure. Forced vital capacity (FVC) was determined before and after exposure, as well as 5 min after each exercise period. Heart rate was monitored throughout the exposure, and metabolic functions were measured during the last 2 min of each exercise period. There were no changes in any variable consequent to FA or PAN exposure. During O/sub 3/ and PAN/O/sub 3/ exposures, a decrease in V/sub T/, a concomitant increase in f/sub R/, and no change in V/sub E/ occurred. Both O/sub 3/ and PAN/O/sub 3/ induced significant (p < 0.05) decrements in FVC, FEV/sub 1.0/, FEV/sub 2.0/, FEV/sub 3.0/, FEF25-75 %, IC, ERV, and TLC, but following PAN/O/sub 3/ exposure the decrements were 10 percent greater. The results suggest an interactive effect between PAN and O/sub 3/. A comparison of data from this study and a similar study on men exercising at equivalent V/sub E/ found no difference in the pulmonary responses to the pollutants between men and women.

• Research Organization: Univ. of California, Santa Barbara
• OSTI ID: 5801429
• Journal Information: J. Air Pollut. Control Assoc.; (United States), Journal Name: J. Air Pollut. Control Assoc.; (United States) Vol. 36:3; ISSN JPCAA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism &amp; Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
ESTERS
FEMALES
HAZARDS
HEALTH HAZARDS
INHIBITION
MAMMALS
MAN
NITRATES
NITRIC ACID ESTERS
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
OZONE
PEROXYACETYL NITRATE
PRIMATES
RESPIRATION
RESPIRATORY SYSTEM
SYNERGISM
VERTEBRATES
WOMEN