Production of interferon-gamma by in vivo tumor-sensitized T cells: Association with active antitumor immunity
- Bristol-Myers Company, Wallingford, CT (USA)
The state of active immunity to Meth A fibrosarcoma in mice immunized with an admixture of Meth A cells and Propionibacterium acnes is associated with possession by the host of spleen cells capable of producing interferon-gamma (IFN-gamma) upon in vitro restimulation with irradiated tumor cells. The ability of spleen cells from immunized mice to produce IFN-gamma in response to irradiated Meth A cells decays as active antitumor immunity is replaced by a state of immunological memory. The IFN-producing cells are L3T4+Ly2+, cyclophosphamide-sensitive and radiosensitive T cells, as determined by their sensitivity to corresponding monoclonal antibodies and complement. The induction of IFN-gamma production by in vivo tumor-sensitized T cells is tumor specific, in that spleen cells from mice immunized against Meth A fibrosarcoma can produce IFN in response to irradiated Meth A cells but not in response to another syngeneic tumor M109 lung carcinoma.
- OSTI ID:
- 7044644
- Journal Information:
- Journal of Interferon Research; (USA), Vol. 10:1; ISSN 0197-8357
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
INTERFERON
BIOSYNTHESIS
LYMPHOCYTES
RADIOSENSITIVITY
TUMOR CELLS
BIOLOGICAL RADIATION EFFECTS
COMPLEMENT
FIBROSARCOMAS
GAMMA RADIATION
IMMUNITY
MICE
MONOCLONAL ANTIBODIES
SPLEEN CELLS
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
GROWTH FACTORS
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOKINES
MAMMALS
MATERIALS
MITOGENS
NEOPLASMS
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RODENTS
SARCOMAS
SOMATIC CELLS
SYNTHESIS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560120 - Radiation Effects on Biochemicals
Cells
& Tissue Culture