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Suppressive effect of x-irradiated tumor cell presensitization on the induction of syngeneic tumor immunity. II. Opposite effects of intravenous administration of TNP-conjugated tumor cells on the development of antitumor and anti-TNP-self cytotoxic effector cells

Journal Article · · Cell. Immunol.; (United States)
;
A comparison was made of the effects of iv inoculation of trinitrophenyl (TNP)-conjugated syngeneic X5563 tumor cells on the development of anti-TNP-modified self (TNP-self) and anti-X5563 tumor-specific T-cell-mediated cytotoxic responses. Administration of syngeneic TNP-conjugated spleen cells or x-irradiated TNP-conjugated X5563 cells resulted in an appreciable augmentation in the generation of TNP-reactive cytotoxic effector cell activity as measured by subsequent in vitro sensitization with TNP-self. In contrast, iv inoculation with either TNP-modified or unmodified x-irradiated X5563 tumor cells did not prime mice for antitumor cytotoxic responses, but abolished the ability of mice to develop antitumor cytotoxic effector cells even after effective in vivo immunization with tumor cells. The possible mechanisms by which the suppression of antitumor cytotoxic response was induced by conditions which simultaneously induced an enhanced anti-TNP-self cytotoxic response are discussed.
Research Organization:
National Cancer Inst., Bethesda, MD
OSTI ID:
6538355
Journal Information:
Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 59:1; ISSN CLIMB
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
IMMUNITY
IMMUNOLOGY
IMMUNOSUPPRESSION
INJECTION
INTAKE
INTRAVENOUS INJECTION
IONIZING RADIATIONS
MAMMALS
MICE
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TUMOR CELLS
VERTEBRATES
X RADIATION