Cobalt-60 plaque radiotherapy vs enucleation for posterior uveal melanoma

Journal Article · Tue May 15 00:00:00 EDT 1990 · American Journal of Ophthalmology; (USA)

DOI:https://doi.org/10.1016/S0002-9394(14)70691-9· OSTI ID:7044055

Augsburger, J J; Gamel, J W; Lauritzen, K; Brady, L W ^[1]

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1. Retina Service, Wills Eye Hospital, Philadelphia, PA (USA)

We compared the survival of 302 patients with a primary choroidal or ciliary body melanoma treated by cobalt-60 plaque radiotherapy between 1976 and 1982 with the survival of 134 patients treated by enucleation during the same period. Tumor size, location of the anterior margin of the tumor, and patient age at the time of treatment were identified as simultaneous significant clinical variables for predicting melanoma-specific mortality by multivariate Cox proportional hazards modeling. We computed a prognostic index for each patient based on this model and found that patients in the enucleation group had slightly higher values of this index than did patients in the cobalt-60 plaque radiotherapy group. Risk ratios for the treatment effect computed from a Cox model incorporating prognostic index and the treatment variable were found to be approximately equal to 1, both for analysis of melanoma-specific mortality and total mortality. These results indicate that when one controls for differences in prognostic index between the groups, cobalt-60 plaque therapy and enucleation are essentially equivalent in their effect on survival.

• OSTI ID: 7044055
• Journal Information: American Journal of Ophthalmology; (USA), Journal Name: American Journal of Ophthalmology; (USA) Vol. 109:5; ISSN AJOPA; ISSN 0002-9394
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DISEASES
EYES
FACE
HEAD
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATHEMATICS
MEDICINE
MELANOMAS
MINUTES LIVING RADIOISOTOPES
MORTALITY
MULTIVARIATE ANALYSIS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATIENTS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
STATISTICS
SURVIVAL CURVES
THERAPY
UVEA
YEARS LIVING RADIOISOT