Enucleation vs cobalt plaque radiotherapy for malignant melanomas of the choroid and ciliary body

Journal Article · Thu May 01 04:00:00 EDT 1986 · Arch. Ophthalmol. (Chicago); (United States)

DOI:https://doi.org/10.1001/archopht.1986.01050170045019· OSTI ID:5618789

Augsburger, J J; Gamel, J W; Sardi, V F; Greenberg, R A; Shields, J A; Brady, L W

Clinical risk factors were assessed prospectively in a nonrandomized concurrent observational study of 237 patients with posterior uveal malignant melanoma. One hundred forty of these patients were treated with enucleation, and 97 underwent cobalt plaque radiotherapy. Tumor size and location of the anterior tumor margin proved to be the most significant clinical risk factors for death from metastatic melanoma. When Cox proportional hazards modeling was used to adjust for recognized intergroup differences in risk factors, the effect of therapy (enucleation vs cobalt plaque radiotherapy) on survival time was not statistically significant. We discuss the implications of this study for a randomized clinical trial of enucleation vs cobalt plaque therapy or comparable forms of irradiation.

• Research Organization: Thomas Jefferson Univ., Philadelphia, PA
• OSTI ID: 5618789
• Journal Information: Arch. Ophthalmol. (Chicago); (United States), Journal Name: Arch. Ophthalmol. (Chicago); (United States) Vol. 5; ISSN AROPA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
BODY AREAS
COBALT ISOTOPES
DISEASES
EYES
FACE
HEAD
ISOTOPES
MEDICINE
MELANOMAS
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
RADIOTHERAPY
RISK ASSESSMENT
SENSE ORGANS
SURVIVAL TIME
THERAPY
UVEA