Differences in cell-cycle progression delays after exposure to /sup 238/Pu. cap alpha. particles compared to x rays

Journal Article · Wed Oct 01 04:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575213· OSTI ID:7029951

Raju, M R; Johnson, T S; Tokita, N; Carpenter, S; Jett, J H

Cultured Chinese hamster cells (V79) were exposed to /sup 238/Pu ..cap alpha.. particles or 250 kVp x rays at doses resulting in similar cell survivals (i.e., 50, 10, and 1%). The DNA distributions of cells at different times after radiation exposure were measured using flow cytometry. Results indicated that after exposure to ..cap alpha.. particles, V79 cells showed significantly prolonged late S phase delay compared to x rays for comparable cell-killing doses. Retention of cells in late S subsequent to ..cap alpha..-particle exposure caused a longer mitotic delay compared to x rays for a given survival level, consistent with the observation that for the endpoint of mitotic delay the RBE for high-LET radiation is higher than the RBE for cell killing.

• Research Organization: Univ. of California, Los Alamos, NM
• OSTI ID: 7029951
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 84:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CELL CYCLE
CELL DIVISION
CELL FLOW SYSTEMS
CELL KILLING
CHARGED PARTICLES
COMPARATIVE EVALUATIONS
DATA
DNA
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
ENERGY TRANSFER
EVEN-EVEN NUCLEI
EXPERIMENTAL DATA
HAMSTERS
HEAVY NUCLEI
INFORMATION
IONIZING RADIATIONS
ISOTOPES
LET
LETHAL DOSES
MAMMALS
MITOSIS
NUCLEI
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
PLUTONIUM 238
PLUTONIUM ISOTOPES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RBE
RODENTS
SURVIVAL CURVES
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES