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Chemotherapy response as a prognosticator for survival in patients with limited squamous cell lung cancer treated with combined chemotherapy and radiotherapy

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
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Twenty-two patients with limited unresectable squamous cell lung cancer were treated with 6 courses of combination chemotherapy consisting of cyclophosphamide, adriamycin, cisplatin, and bleomycin (CAP-Bleo) and short-course thoracic irradiation started after the first 4 weeks of chemotherapy. Of 20 patients with visible tumor who were treated with 4 weeks of chemotherapy alone, 10 (50%) had a tumor regression in that 4 week period and 10 did not. Those patients with tumor regression had significantly better progression free and overall survivals than did patients with no chemotherapy regressions (medians of 258 days vs. 136 days and 356 days vs. 150 days respectively). The original bleomycin dose had to be reduced by 50% primarily because of excessive radiation esophagitis that has not been reported with use of either the CAP regimen or bleomycin along in conjunction with thoracic irradiation. An initial chemotherapy regression seems to be a good prognosticator for progression-free and overall survival in patients with limited squamous cell lung cancer treated with combined chemotherapy and radiotherapy.
Research Organization:
Mayo Clinic, Rochester, NY
OSTI ID:
7029379
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:7; ISSN IOBPD
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ALKYLATING AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLEOMYCIN
BLOOD COUNT
BODY
BODY AREAS
CARCINOMAS
CHEMOTHERAPY
CHEST
DIGESTIVE SYSTEM
DISEASES
DOSES
DOXORUBICIN
DRUGS
ENDOXAN
ENERGY RANGE
ESOPHAGUS
HEMIC DISEASES
INFLAMMATION
LEUKOPENIA
LINEAR ACCELERATORS
LUNGS
MEV RANGE
MEV RANGE 01-10
NEOPLASMS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
SIDE EFFECTS
SYMPTOMS
THERAPY