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Combination of cis-platinum and bleomycin prior to surgery and/or radiotherapy compared with radiotherapy alone for the treatment of advanced squamous cell carcinoma of the head and neck

Journal Article · · Cancer (Philadelphia); (United States)
; ;
Forty-one patients with unresectable Stage IV head and neck squamous cell carcinoma were treated with combined modality therapy (CM) consisting of induction chemotherapy followed by surgery and/or radiotherapy (RT). Treatment and survival results are reported and compared to results obtained in treating 41 historic controls with RT alone. No patient had distant metastases. Patients in the CM group received cis-platinum (DDP) 120 mg/m/sup 2/ on days 1 and 22 with prehydration and mannitol diuresis and bleomycin 15 ..mu../m/sup 2/ as a continuous infusion between days 3-9 started after a 15 ..mu../m/sup 2/ IV push. Patients underwent reendoscopy two weeks after completing chemotherapy to evaluate response. Subsequent surgery and/or radiotherapy were administered depending on tumor resectability after chemotherapy. Induction chemotherapy with DDP and bleomycn infusion followed by surgery and/or radiotherapy appears to be associated with a higher CR rate and prolonged survival compared to RT alone. (JMT)
Research Organization:
Boston Veterans Administration Medical Center, MA
OSTI ID:
5742910
Journal Information:
Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 50:12; ISSN CANCA
Country of Publication:
United States
Language:
English

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Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE EARTH METALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLEOMYCIN
BODY
BODY AREAS
CARCINOMAS
CHEMOTHERAPY
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELEMENTS
EXTERNAL IRRADIATION
GOLD 198
GOLD ISOTOPES
HEAD
HEAVY NUCLEI
IMPLANTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
METALS
MINUTES LIVING RADIOISOTOPES
NECK
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
PLATINUM COMPOUNDS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RADIUM
SIDE EFFECTS
SURGERY
SURVIVAL TIME
THERAPY
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES