Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Randomized comparison of radiotherapy with a radiotherapy-chemotherapy combination in Stage IV carcinoma of the head and neck. [/sup 60/Co]

Conference · · Cancer; (United States)
OSTI ID:6442563
; ; ; ; ; ;
Between 1975 and 1978, 23 patients with Stage IV, unresectable, squamous cell carcinoma of the head and neck were randomized to receive radiotherapy (RT, 11 patients), or radiotherapy-chemotherapy (RT and CT, 12 patients). The response rate for the 12 RT and CT patients was four complete remissions (CR) and four partial remissions (PR); the 11 RT patients had one CR and three PR. The median survival of the RT and CT group was 12 months compared with 5.6 months for the RT group (P = 0.13). The present chemotherapy regimen did not modify the pattern of failure and only marginally increased patient survival. It did, however, increase the response rate. The authors plan to reactivate the trial with modification in the induction chemotherapy and the addition of postradiation maintenance CT consisting of sequential bleomycin and cis-platinum.
Research Organization:
Wadsworth Medical Center, Los Angeles, CA
OSTI ID:
6442563
Conference Information:
Journal Name: Cancer; (United States) Journal Volume: 47:9
Country of Publication:
United States
Language:
English

Similar Records

Involved-field radiotherapy for patients in partial remission after chemotherapy for advanced Hodgkin's lymphoma
Journal Article · Sun Dec 31 23:00:00 EST 2006 · International Journal of Radiation Oncology, Biology and Physics · OSTI ID:20850290
Radiotherapy and bleomycin-containing chemotherapy in the treatment of advanced head and neck cancer: report of six patients and review of the literature
Journal Article · Thu Oct 01 00:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:5923465
Combination of cis-platinum and bleomycin prior to surgery and/or radiotherapy compared with radiotherapy alone for the treatment of advanced squamous cell carcinoma of the head and neck
Journal Article · Tue Dec 14 23:00:00 EST 1982 · Cancer (Philadelphia); (United States) · OSTI ID:5742910

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ALKALOIDS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLEOMYCIN
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY AREAS
BODY FLUIDS
CARCINOMAS
CHEMOTHERAPY
CITROVORUM FACTOR
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DISEASES
DRUGS
EDEMA
ELECTROMAGNETIC RADIATION
ENERGY RANGE
GAMMA RADIATION
HEAD
HEMIC DISEASES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOPENIA
LINEAR ACCELERATORS
MATERIALS
MEDICINE
MEMBRANES
METHOTREXATE
MEV RANGE
MEV RANGE 01-10
MINUTES LIVING RADIOISOTOPES
MUCOUS MEMBRANES
NECK
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ONCOVIN
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PATIENTS
PLATINUM COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURVIVAL TIME
SYMPTOMS
THERAPY
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES