Randomized trial of thoracic irradiation plus combination chemotherapy for unresectable adenocarcinoma and large cell carcinoma of the lung
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5339454
Sixty-eight evaluable patients with unresectable adenocarcinoma and large cell carcinoma of the lung were treated on a prospective randomized trial comparing thoracic radiation therapy (TRT) plus combination chemotherapy with either cyclophosphamide, Adriamycin and cis-platinum (CAP) or cyclophosphamide, Adriamycin (same dosages) and DTIC (CAD), 34 on each arm. Patients treated with TRT plus CAP had a better overall regression rate (59% vs 47%) and a statistically significant superiority in time to disease progression (147 days vs 303 days) and survival (217 days vs 504 days).
- Research Organization:
- Mayo Clinic, Rochester, MN
- OSTI ID:
- 5339454
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
CHEMOTHERAPY
CHEST
COMPLEXES
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOXORUBICIN
DRUGS
ENDOXAN
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
INFORMATION
IRRADIATION
ISOLATED VALUES
LOCAL IRRADIATION
LUNGS
NEOPLASMS
NUMERICAL DATA
ORGANS
PATIENTS
PLATINUM COMPLEXES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
SIDE EFFECTS
SURVIVAL TIME
THERAPY
TOXICITY
TRANSITION ELEMENT COMPLEXES
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
CHEMOTHERAPY
CHEST
COMPLEXES
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOXORUBICIN
DRUGS
ENDOXAN
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
INFORMATION
IRRADIATION
ISOLATED VALUES
LOCAL IRRADIATION
LUNGS
NEOPLASMS
NUMERICAL DATA
ORGANS
PATIENTS
PLATINUM COMPLEXES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
SIDE EFFECTS
SURVIVAL TIME
THERAPY
TOXICITY
TRANSITION ELEMENT COMPLEXES