Mechanisms of hypertension in renal radiation

Journal Article · Thu Feb 01 00:00:00 EST 1990 · Hypertension (Dallas); (USA)

DOI:https://doi.org/10.1161/01.HYP.15.2_Suppl.I132· OSTI ID:7025195

Juncos, L; Cornejo, J C; Cejas, H; Broglia, C ^[1]

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1. Instituto Privado de Especialidades Medicas, Cordoba (Argentina)

This study was undertaken to investigate the role played by renal functional and structural changes in the development of radiation-induced hypertension. Four groups of rats were studied: (1) left kidney radiated, (2) sham procedure, (3) uninephrectomy followed 3 weeks later by radiation of the contralateral kidney, and (4) uninephrectomy followed by sham procedure 3 weeks later. All radiated rats became hypertensive at 12 weeks (p less than 0.05) and had higher protein excretion (p less than 0.05). In the presence of an intact contralateral kidney, radiation causes mild-to-moderate histological abnormalities, and therefore, creatinine clearance and water and sodium handling do not change. Plasma renin activity increased in this group (p less than 0.05). Radiated uninephrectomized rats showed decreased creatinine clearance (p less than 0.05), but renin activity remained unchanged. These rats developed severe histological abnormalities in glomeruli, interstitia, tubuli, and vessels resulting in increased sodium and water output. The average of individual tubular and interstitial scores correlated significantly with both water intake and output but not with sodium excretion. These studies suggest that in the presence of an intact kidney, renin is an important determinant in the development or maintenance of radiation hypertension, whereas in the absence of the contralateral kidney, severe histological changes and renal failure are prominent despite increased water intake and output. The more severe glomerular sclerosis and proteinuria in the latter model could be related to diminished renal mass.

• OSTI ID: 7025195
• Journal Information: Hypertension (Dallas); (USA), Vol. 15:2 Suppl; ISSN 0194-911X
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HYPERTENSION
RADIOINDUCTION
KIDNEYS
BIOLOGICAL RADIATION EFFECTS
BLOOD PRESSURE
CREATININE
MORPHOLOGICAL CHANGES
NEPHRECTOMY
RADIATION INJURIES
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DISEASES
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMINES
INJURIES
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ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
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RODENTS
SURGERY
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals