Effects of ozone on lung tissue of E-supplemented rats

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:7024370

Coleman, R D; Abedin, M Z; Alfin-Slater, R B

The effects of dietary vitamin E (E) in protecting lung tissue of rats exposed to ozone were studied in male, pathogen-free Sprague-Dawley rats fed synthetic diets containing 0, 10 and 50 IU E/Kg for 6 wks. Thereafter, half of the animals in each group were exposed to 0.8 ppm ozone for 4 days, the other half to filtered air, then all animals were killed. Plasma E levels increased with increasing dietary E in both ozone-exposed and air-breathing rats; values in both groups were 12 times higher at 50 IU than what was observed in E-free dietary controls. Even greater increases were seen in lung and liver. Ozone enhanced the observed increased levels in the lung but diminished those in the liver. Ozone produced lipid oxidation in the lung at 0 and 10 IU E as measured by a modified TBA test whereas 50 IU was protective. In the lung, mean organ weight, cytosolic protein content, and activities of NADPH-generating and sulfhydryl-metabolizing enzymes were not affected by the level of dietary E in air-breathing controls. Ozone exposure, however, increased these indices but the extent of increase varied inversely with the E level in the tissue. It is suggested that the enhanced enzyme activity and lipid oxidation in the lung reflects injury from ozone exposure. Reduction in the extent of these changes with increased tissue E suggests that dietary vitamin E may offer protection against the oxidant-induced lung injury.

• Research Organization: Univ. of California School of Public Health, Los Angeles
• OSTI ID: 7024370
• Report Number(s): CONF-8604222-
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:4; ISSN FEPRA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
ENZYME ACTIVITY
INJURIES
LIPIDS
LUNGS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
OZONE
RATS
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VERTEBRATES
VITAMIN E
VITAMINS